HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobenzamide → 4'-(5-Aminopyrazin-2-yl)-3'-fluorobiphenyl-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobenzamide | HCID 77616 | — |
| Reactant | 5-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl)-pyrazin-2-amine | HCID 90312276 | — |
| Product | 4'-(5-Aminopyrazin-2-yl)-3'-fluorobiphenyl-2-carboxamide | HCID 90313347 | — |
Reaction Steps
The title compound was prepared using analogous conditions to those described in Example 1 utilizing 5-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrazin-2-amine and 2-bromobenzamide. MS (ESI): mass calcd. for C17H13FN4O, 308.11; m/z found, 309.0 [M+H]+. 1H NMR (400 MHz, DMSO-d6) δ 8.35 (s, 1H), 8.01 (s, 1H), 7.86 (m, 1H), 7.75 (s, 1H), 7.55-7.26 (m, 7H), 6.70 (s, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079866B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-fe59b29c374c4d8c96b77ac7a040678f |
| Source note | uspto-grants-2015_07 |