2-Bromo-N-tert-butyl-5-fluorobenzamide → HCID 90314092, compound

HRID 1524002Notes

Reaction equation

HRID 1524002 reaction equation
[F:1][C:2]1[CH:7]=[C:6](B2OC(C)(C)C(C)(C)O2)[CH:5]=[CH:4][C:3]=1[C:17]1[N:18]=[CH:19][C:20]([NH2:23])=[N:21][CH:22]=1.Br[C:25]1[CH:37]=[CH:36][C:35]([F:38])=[CH:34][C:26]=1[C:27]([NH:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28]>>[NH2:23][C:20]1[N:21]=[CH:22][C:17]([C:3]2[CH:4]=[CH:5][C:6]([C:25]3[C:26]([C:27]([NH:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])=[CH:34][C:35]([F:38])=[CH:36][CH:37]=3)=[CH:7][C:2]=2[F:1])=[N:18][CH:19]=1

Participants

3

Reactant 2

HCID 247005652-Bromo-N-tert-butyl-5-fluorobenzamideHCID 903122765-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl)-pyrazin-2-amine

Product 1

HCID 90314092HCID 90314092, compound

Procedure

The title compound was prepared using methods analogous to those described in Example 369 using 5-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrazin-2-amine and 2-bromo-N-(tert-butyl)-5-fluorobenzamide. MS (ESI): mass calcd. for C21H20F2N4O, 382.16; m/z found, 383.2 [M+H]+.

Sources & evidence

ORD record
ord-ec2bbddb701c4c4caf864a0a60683d6e
Source dataset
uspto-grants-2015_07
Patent number
US09079866B2

Reaction notes

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