4-Piperidinamine → HCID 90314721, compound

HRID 1524015Notes

Reaction equation

HRID 1524015 reaction equation
[NH2:1][C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[C:15]([C:20](O)=[O:21])=[CH:16][CH:17]=[CH:18][CH:19]=3)=[CH:10][C:9]=2[F:23])=[CH:4][N:3]=1.[NH:24]1[CH2:29][CH2:28][CH:27]([NH2:30])[CH2:26][CH2:25]1>>[NH2:30][CH:27]1[CH2:28][CH2:29][N:24]([C:20]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[C:11]2[CH:12]=[CH:13][C:8]([C:5]3[N:6]=[CH:7][C:2]([NH2:1])=[N:3][CH:4]=3)=[C:9]([F:23])[CH:10]=2)=[O:21])[CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 4243614-PiperidinamineHCID 90313349HCID 90313349, compound

Product 1

HCID 90314721HCID 90314721, compound

Procedure

The title compound was prepared using methods analogous to those described in Step C of Example 504 using 4′-(2-aminopyrazin-5-yl)-3′-fluoro-[1,1′-biphenyl]-2-carboxylic acid and piperidin-4-amine. MS (ESI): mass calcd. for C22H22FN5O, 391.18; m/z found, 392.1 [M+H]+. 1H NMR (400 MHz, DMSO-d6) δ 8.34 (s, 1H), 7.99 (s, 1H), 7.88 (s, 1H), 7.48 (d, J=14.8, 3H), 7.35-7.20 (m, 3H), 6.69 (s, 2H), 4.31 (s, 1H), 3.08-2.50 (m, 6H), 1.75 (t, J=80.9, 2H), 1.38-0.86 (m, 2H).

Sources & evidence

ORD record
ord-6a15e103de3f43f188a535702539d88c
Source dataset
uspto-grants-2015_07
Patent number
US09079866B2

Reaction notes

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