4-Acetyl-3-fluorophenylboronic acid → 1-[3-Fluoro-2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl]ethanone

Participants

Reaction Steps

The title compound was prepared using conditions analogous to those described in Example 1 using (4-acetyl-3-fluorophenyl)boronic acid and 1-(2-bromo-phenylsulfonyl)pyrrolidine. MS (ESI): mass calcd. for C18H18FNO3S, 347.10; m/z found, 348.0 [M+H]+. 1H NMR (500 MHz, CDCl3) δ 8.10 (dd, J=7.9, 1.3, 1H), 7.95-7.89 (m, 1H), 7.63-7.58 (m, 1H), 7.58-7.51 (m, 1H), 7.30-7.27 (m, 2H), 7.26-7.25 (m, 1H), 2.98-2.90 (m, 4H), 2.69 (d, J=4.9, 3H), 1.76-1.67 (m, 4H).

Provenance & Evidence