Boronic acid, B-(2-(((1,1-dimethylethyl)amino)sulfonyl)phenyl)- → HCID 90313045, compound

HRID 1524052Notes

Reaction equation

HRID 1524052 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([NH2:13])[O:11][CH:12]=2)=[C:4]([F:14])[CH:3]=1.[C:15]([NH:19][S:20]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1B(O)O)(=[O:22])=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[NH2:13][C:10]1[O:11][CH:12]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([C:24]3[C:23]([S:20]([NH:19][C:15]([CH3:18])([CH3:17])[CH3:16])(=[O:21])=[O:22])=[CH:28][CH:27]=[CH:26][CH:25]=3)=[CH:3][C:4]=2[F:14])[N:9]=1

Participants

3

Reactant 2

HCID 4997616Boronic acid, B-(2-(((1,1-dimethylethyl)amino)sulfonyl)phenyl)-HCID 82973661HCID 82973661, compound

Product 1

HCID 90313045HCID 90313045, compound

Procedure

The title compound was prepared using methods described in Example 427 using 4-(4-bromo-2-fluorophenyl)oxazol-2-amine and (2-(N-(tert-butyl)sulfamoyl)phenyl)boronic acid. MS (ESI): mass calcd. for C19H20FN3O3S, 389.12; m/z found, 390.2 [M+H]+. 1H NMR (500 MHz, CDCl3) δ 8.18 (dd, J=7.9, 1.4, 1H), 7.98 (m, 1H), 7.66 (d, J=4.2, 1H), 7.57 (m, 1H), 7.54-7.48 (m, 1H), 7.38-7.30 (m, 3H), 4.63 (s, 2H), 3.64 (s, 1H), 1.03 (s, 9H).

Sources & evidence

ORD record
ord-981ebdc312344c5a877670bad872e09d
Source dataset
uspto-grants-2015_07
Patent number
US09079866B2

Reaction notes

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