Morpholine, 4-(chloroacetyl)- → HCID 47218134, compound

HRID 1524060Notes

Reaction equation

HRID 1524060 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([CH2:11][C:12]([NH2:14])=[O:13])(=[O:10])=[O:9].ClCC(N1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1)=O>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([CH2:11][C:12]([N:14]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1)=[O:13])(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 74040Morpholine, 4-(chloroacetyl)-HCID 47218127HCID 47218127, compound

Product 1

HCID 47218134HCID 47218134, compound

Procedure

The title compound was prepared in a manner similar to that described for 2-((2-bromophenyl)sulfonyl)acetamide using 2-chloro-1-morpholinoethanone in Step A. 1H NMR (600 MHz, DMSO-d6) δ 8.06-8.01 (m, 1H), 7.93-7.88 (m, 1H), 7.68-7.60 (m, 2H), 4.84 (s, 2H), 3.63-3.55 (m, 4H), 3.53-3.48 (dd, J=5.6, 4.0, 2H), 3.42-3.37 (d, J=5.2, 2H).

Sources & evidence

ORD record
ord-29a7d4eb31b54d24bc8fa0afa1eae89a
Source dataset
uspto-grants-2015_07
Patent number
US09079866B2

Reaction notes

Loading…