Ethanolamine → HCID 90312825, compound

HRID 1524065Notes

Reaction equation

HRID 1524065 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[C:15]([C:24](O)=O)=[CH:16][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:18][CH:19]=3)=[CH:10][C:9]=2[F:27])=[N:6][CH:7]=1.[CH2:28]([CH2:30][NH2:31])[OH:29]>>[NH2:1][C:2]1[N:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:16][C:15]=3[CH2:24][NH:31][CH2:30][CH2:28][OH:29])=[CH:10][C:9]=2[F:27])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 90313214HCID 90313214, compound

Product 1

HCID 90312825HCID 90312825, compound

Procedure

The title compound was prepared using analogous conditions to those described in Intermediate IF using 4′-(5-Aminopyrazin-2-yl)-3′-fluoro-4-(trifluoromethyl)biphenyl-2-carboxylic acid and ethanolamine. MS (ESI): mass calcd. for C20H18F4N4O, 406.39; m/z found, 407.1 [M+H]+. 1H NMR (400 MHz, CD3OD) δ 8.41 (s, 1H), 8.18 (s, 1H), 8.12-8.01 (m, 2H), 7.86 (dd, J=8.1, 1.7, 1H), 7.65 (d, J=8.1, 1H), 7.34 (dd, J=3.5, 1.6, 1H), 7.33-7.31 (m, 1H), 4.38 (s, 2H), 3.78-3.63 (m, 2H), 3.09-3.00 (m, 2H).

Sources & evidence

ORD record
ord-27d4f6e16dad450b9dc45cd247bfb74b
Source dataset
uspto-grants-2015_07
Patent number
US09079866B2

Reaction notes

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