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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1524068Generated: November 4, 2026

HCID 60727074, compound → HCID 90313956, compound

https://huagongshe.com/reaction/1524068

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 60727074HCID 60727074—
Reactant5-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrimidin-2-amineHCID 90313142—
ProductHCID 90313956HCID 90313956—

Reaction Steps

The title compound was prepared in a manner similar to that described in Example 88 using 2-(2-bromophenoxy)-4-(trifluoromethyl)pyrimidine and 5-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrimidin-2-amine. MS (ESI): mass calcd. for C21H13F4N5O, 427.11; m/z found, 428.0 [M+H]+. 1H NMR (400 MHz, DMSO-d6) δ 8.93 (d, J=4.9, 1H), 8.41 (d, J=1.4, 2H), 7.69 (d, J=4.9, 1H), 7.60-7.57 (m, 1H), 7.55-7.50 (m, 2H), 7.46-7.38 (m, 2H), 7.35-7.29 (m, 2H), 6.88 (s, 2H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09079866B2
Source datasetuspto-grants-2015_07
ORD IDord-04a4a4c06c504a8696ee7a1369760970
Source noteuspto-grants-2015_07