HRID1524109

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4825014

2-bromo-N-tert-butylbenzenesulfonamide

C10H14BrNO2S

结构：CC1(C)OB(c2ccc(-c3cnc(N)nc3)nc2)OC1(C)C

HCID90314121

5-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-2-pyrimidinamine

C15H19BN4O2

PRODUCTS

生成物

结构：CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)nc1

HCID90313296

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in a manner similar to that described in Example 427 using 5-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)pyrimidin-2-amine and 2-bromo-N-(tert-butyl)benzenesulfonamide. MS (ESI): mass calcd. for C19H21N5O2S, 383.14; m/z found, 384.1 [M+H]+. 1H NMR (400 MHz, CD3OD) δ 8.96 (s, 2H), 8.62 (dd, J=2.3, 0.9, 1H), 8.34 (d, J=1.8, 1H), 8.01 (dd, J=8.0, 1.6, 1H), 7.94 (dd, J=8.2, 2.3, 1H), 7.87 (dd, J=8.2, 0.9, 1H), 7.65 (d, J=7.9, 1H), 2.84 (q, J=7.2, 2H), 1.01 (t, J=7.2, 3H).