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HRID1524110

反应详情

EQUATION

反应方程式

HRID 1524110 的结构方程式

REACTANTS

反应物

2
结构：C[C@H](CO)NS(=O)(=O)c1ccccc1Br
HCID79027397

未命名化合物

结构：CC1(C)OB(c2ccc(-c3cnc(N)nc3)nc2)OC1(C)C
HCID90314121

5-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-2-pyrimidinamine

C15H19BN4O2

PRODUCTS

生成物

1
结构：C[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)nc1
HCID90314053

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in a manner similar to that described in Example 427 using 5-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)pyrimidin-2-amine and (R)-2-bromo-N-(1-hydroxypropan-2-yl)benzenesulfonamide. MS (ESI): mass calcd. for C18H19N5O3S, 385.12; m/z found, 386.1 [M+H]+. 1H NMR (400 MHz, CD3OD) δ 8.92 (s, 2H), 8.66-8.56 (m, 1H), 8.19 (dd, J=8.0, 1.4, 1H), 7.95 (dd, J=8.2, 2.3, 1H), 7.83 (dd, J=8.2, 0.9, 1H), 7.72 (m, 1H), 7.64 (m, 1H), 7.43 (dd, J=7.5, 1.4, 1H), 3.43-3.16 (m, 4H), 1.03 (d, J=6.6, 3H).