反应详情

温度

50 °C

Add to a solution of trans-3-(3-cyano-phenylcarbamoyl)-4-(3-methoxycarbonyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.20 g, 0.44 mmol) in MeOH (3 mL), sodium hydroxide as a 10% aqueous solution (0.40 mL, 1.00 mmol). Heat the mixture to 50° C. for 30 min then cool to room temperature and remove the MeOH under reduced pressure. Dilute the mixture with water and adjust the pH to approximately pH 5 by the addition of a 2 N solution of hydrochloric acid causing a solid to precipitate from solution. Collect the formed solid by filtration, wash with water and dry on the filter pad to provide 0.17 g of trans-3-(3-carboxy-phenyl)-4-(3-cyano-phenylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester as a powder.

1. temperaturethen cool to room temperature
2. customremove the MeOH under reduced pressure
3. additionDilute the mixture with water
4. additionby the addition of a 2 N solution of hydrochloric acid causing a solid
5. customto precipitate from solution
6. customCollect the formed solid
7. filtrationby filtration
8. washwash with water
9. customdry on the filter pad