Potassium Carbonate → HCID 57520337, compound

Participants

Reaction Steps

1.5 195 mg (1.40 mmol) of potassium carbonate are added to a solution of 197 mg (0.56 mmol) of tert-butyl 5-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-(2-methoxy-ethoxy)pyrrolo[2,3-d]pyrimidine-7-carboxylate in 2.8 ml of methanol, and the mixture is stirred at room temperature for 1 hour. The reaction mixture is adsorbed onto kieselguhr and chromatographed on a silica-gel column with dichloromethane/methanol/ammonia water as eluent: 5-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-(2-methoxyethoxy)-7H-pyrrolo[2,3-d]pyrimidine (“A1”) as colourless crystals; m.p. 240° C.;

Provenance & Evidence