Ammonium Chloride → HCID 86708061, compound

Participants

Reaction Steps

To a stirred solution of the material from Step 6 (1.17 g, 1.833 mmol) in dichloromethane (22 mL) and ethanol (14 mL) was added sodium borohydride (347 mg, 9.17 mmol). The reaction mixture was stirred at room temperature for 2 hours, poured into saturated aqueous NH4Cl and extracted with dichloromethane (2×). The combined organics were washed with saturated aqueous NaHCO3 and brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography on silica gel using EtOAc-hexanes to afford 625 mg of the title compound. LCMS (M+Na)=660.

Provenance & Evidence