Ammonium Chloride → HCID 86708063, compound

Participants

Reaction Steps

To a stirred solution of the material from Step 7 (242 mg, 0.38 mmol) in dichloromethane (3.8 mL) at 0° C. were added N,N-diisopropylaethylamine (99 μL, 0.57 mmol) and methanesulfonyl chloride (33 μL, 0.417 mmol). The reaction mixture was stirred at room temperature overnight, poured into saturated aqueous NH4Cl and extracted with dichloromethane (2×). The combined organics were washed with brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography on silica gel using EtOAc-hexanes to afford 167 mg of the title compound. LCMS (M+Na)=738.

Provenance & Evidence