(3,5-Dimethoxyphenyl)boronic acid → 3-(3,5-dimethoxyphenyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide

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Reaction Steps

The title compound was prepared in an analogous manner to that described in Example 28 using (3,5-dimethoxyphenyl)boronic acid and 3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide, and the desired product, 3-(3,5-dimethoxyphenyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide, was isolated as an off-white solid. 1H NMR (500 MHz, DMSO-d6) δ ppm 3.78-3.88 (m, 9 H) 6.39 (t, J=2.23 Hz, 1 H) 6.77 (d, J=2.29 Hz, 2 H) 7.52 (dd, J=8.42, 1.55 Hz, 1 H) 7.75-7.89 (m, 4 H). m/z (ESI) 430.1 (M+H)+.

Provenance & Evidence