(4-Cyano-3-fluorophenyl)boronic acid → 3-(4-cyano-3-fluorophenyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide

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Reaction Steps

The title compound was prepared in an analogous manner to that described in Example 28 using (4-cyano-3-fluorophenyl)boronic acid and 3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide, and the desired product, 3-(4-cyano-3-fluorophenyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide, was isolated as an off-white solid. 1H NMR (500 MHz, DMSO-d6) δ ppm 3.92 (s, 3 H) 7.60 (dd, J=8.53, 1.55 Hz, 1 H) 7.73-7.80 (m, 2 H) 7.87-7.97 (m, 2 H) 8.02-8.10 (m, 2 H) 8.23 (s, 1 H). m/z (ESI) 413.0 (M+H)+.

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