4-(Trifluoromethoxy)phenylboronic acid → 1-methyl-N-(1,2,4-thiadiazol-5-yl)-3-(4-(trifluoromethoxy)phenyl)-1H-indole-6-sulfonamide

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Reaction Steps

The title compound was prepared in an analogous manner to that described in Example 28 using (4-(trifluoromethoxy)phenyl)boronic acid and 3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide, and the desired product, 1-methyl-N-(1,2,4-thiadiazol-5-yl)-3-(4-(trifluoromethoxy)phenyl)-1H-indole-6-sulfonamide, was isolated as an off-white solid. 1H NMR (500 MHz, DMSO-d6) δ ppm 3.90 (s, 3 H) 7.41 (m, J=8.13 Hz, 2 H) 7.52-7.58 (m, 1 H) 7.74-7.79 (m, 2 H) 7.88-8.00 (m, 4 H). m/z (ESI) 454.0 (M+H)+.

Provenance & Evidence