3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → 1-methyl-N-(1,2,4-thiadiazol-5-yl)-3-(3-(trifluoromethoxy)phenyl)-1H-indole-6-sulfonamide

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Reaction Steps

The title compound was prepared in an analogous manner to that described in Example 28 using (3-(trifluoromethoxy)phenyl)boronic acid and 3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide, and the desired product, 1-methyl-N-(1,2,4-thiadiazol-5-yl)-3-(3-(trifluoromethoxy)phenyl)-1H-indole-6-sulfonamide, was isolated as an off-white solid. 1H NMR (500 MHz, DMSO-d6) δ ppm 3.89 (s, 3 H) 7.22 (d, J=8.25 Hz, 1 H) 7.54-7.58 (m, 3 H) 7.71 (d, J=8.02 Hz, 1 H) 7.87-7.92 (m, 3 H) 7.98 (s, 1 H). m/z (ESI) 454.0 (M+H)+.

Provenance & Evidence