2,4-Dimethoxybenzeneboronic acid → HCID 71259574, compound

Participants

Reaction Steps

The title compound was prepared in an analogous manner to that described in Example 28 using (2,4-dimethoxyphenyl)boronic acid and 3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide, and the desired product, 3-(2,4-dimethoxyphenyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide, was isolated as an off-white solid. 1H NMR (500 MHz, DMSO-d6) δ ppm 3.76 (s, 3H) 3.80 (s, 3H) 3.87 (s, 3H) 6.59-6.68 (m, 2 H) 7.35 (d, J=8.25 Hz, 1 H) 7.43 (dd, J=8.42, 1.43 Hz, 1 H) 7.52-7.60 (m, 1 H) 7.85 (s, 1 H) 7.94 (br. s., 1 H). m/z (ESI) 430.1 (M+H)+.

Provenance & Evidence