2-Chloro-4-methoxybenzeneboronic acid → HCID 71259483, compound

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Reaction Steps

The title compound was prepared in an analogous manner to that described in Example 28 using (2-chloro-4-methoxyphenyl)boronic acid and 3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide, and the desired product, 3-(2-chloro-4-methoxyphenyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide, was isolated as an off-white solid. 1H NMR (500 MHz, DMSO-d6) δ ppm 3.82 (s, 3 H) 3.92 (s, 3 H) 6.96-7.04 (m, 1 H) 7.17 (d, J=2.63 Hz, 1 H) 7.42 (d, J=8.59 Hz, 1 H) 7.45-7.53 (m, 2 H) 7.71 (s, 1 H) 7.93 (s, 1 H) 8.19 (s, 1 H). m/z (ESI) 434.0 (M+H)+.

Provenance & Evidence