Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 6-((R)-sec-Butoxy)-7,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | (-)-2-Butanol | HCID 84682 | — |
| 반응물 | 6-Chloro-7,8-dimethyl-[1,2,4]triazolo[4,3-B]pyridazin-3-amine | HCID 58045804 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6-((R)-sec-Butoxy)-7,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine | HCID 58045798 | — |
반응 단계
(R)-Butan-2-ol (0.5 ml) was deprotonated analogously to W1.056 with sodium hydride (85 mg) and reacted with 6-chloro-7,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine (W2.006a, 100 mg), suspended in DMF (2 ml), and worked up. 75 mg of the title compound were isolated in sufficient purity.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09079906B2 |
| 출처 데이터셋 | uspto-grants-2015_07 |
| ORD ID | ord-a8d2088b45a54ef780ec5fabdb4999d5 |
| 출처 메모 | uspto-grants-2015_07 |