Cyanogen Bromide → HCID 58136895, compound

HRID 1524506Notes

Reaction equation

FC(F)(F)C(O)=O.[Cl:8][C:9]1[N:14]=[N:13][C:12]([NH:15][NH2:16])=[CH:11][C:10]=1[CH:17]1[CH2:19][CH2:18]1.[N:20]#[C:21]Br>>[Cl:8][C:9]1[C:10]([CH:17]2[CH2:19][CH2:18]2)=[CH:11][C:12]2[N:13]([C:21]([NH2:20])=[N:16][N:15]=2)[N:14]=1

Participants

Reactant 2

HCID 10476Cyanogen Bromide

HCID 86650807HCID 86650807, compound

Product 1

HCID 58136895HCID 58136895, compound

Procedure

(6-Chloro-5-cyclopropylpyridazin-3-yl)hydrazine trifluoroacetic acid salt (W3.012; 400 mg) was converted and worked up analogously to W2.008, except that, instead of 0.5, one further equivalent of cyanogen bromide solution was added. 260 mg of the title compound were obtained in sufficient purity.

Sources & evidence

ORD record: ord-2bf8b79132cc46c9828e74e0f2160c21
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09079906B2

Reaction notes

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