Diethyl Ether → HCID 86650812, compound

HRID 1524515Notes

Reaction equation

HRID 1524515 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8][NH2:9])=[C:4]([CH3:10])[C:3]=1[CH3:11].C1([N:15]=[C:16]=[S:17])CC1.C(O[CH2:21][CH3:22])C.[CH2:23](Cl)Cl>>[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8][N:9]([CH:22]2[CH2:21][CH2:23]2)[C:16]([NH2:15])=[S:17])=[C:4]([CH3:10])[C:3]=1[CH3:11]

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 92463Cyclopropyl isothiocyanateHCID 126480423-Chloro-6-hydrazinyl-4,5-dimethylpyridazine

Product 1

HCID 86650812HCID 86650812, compound

Procedure

(6-Chloro-4,5-dimethylpyridazin-3-yl)hydrazine (W3.006, 540 mg) was dissolved in methylene chloride (50 ml), and cyclopropyl isothiocyanate (2900 was added while stirring. The mixture was stirred at RT for 7 h and then left to stand overnight. Thereafter, it was admixed with diethyl ether (50 ml) and stirred for 3 h, and the precipitate formed was filtered off with suction. The precipitate was washed with ether and dried under reduced pressure. 830 mg of the title compound were obtained.

Workup

  1. stirringThe mixture was stirred at RT for 7 h
  2. waitleft
  3. stirringstirred for 3 h
  4. customthe precipitate formed
  5. filtrationwas filtered off with suction
  6. washThe precipitate was washed with ether
  7. customdried under reduced pressure

Sources & evidence

ORD record
ord-6cce5346f729447590980411a1221571
Source dataset
uspto-grants-2015_07
Patent number
US09079906B2

Reaction notes

Loading…