反应详情

1-[3-tert-Butyl-5-(2-methoxy-1-methoxymethylethoxy)phenyl]ethanone (O2.072; 1.64 g) was dissolved in methanol/THF (30/30 ml) and admixed while stirring with phenyltrimethylammonium tribromide (2.09 g). The mixture was stirred at RT for 1 h, then diluted with DCM and washed once with 5% sodium thiosulfate solution. The DCM phase was dried over magnesium sulfate, filtered and concentrated. The residue was purified using silica gel (80 g cartridge, n-heptane/MtB ether gradient of 0-30% within 60 min). 890 mg of the title compound were obtained.

1. washwashed once with 5% sodium thiosulfate solution
2. dry with materialThe DCM phase was dried over magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated
5. customThe residue was purified
6. customsilica gel (80 g cartridge, n-heptane/MtB ether gradient of 0-30% within 60 min)