1-Bromo-3-methoxypropane → 1-[3-Tert-butyl-4-methoxy-5-(3-methoxypropoxy)phenyl]ethanone

HRID 1524574Notes

Reaction equation

HRID 1524574 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([C:14](=[O:16])[CH3:15])[CH:8]=[C:9]([OH:13])[C:10]=1[O:11][CH3:12])([CH3:4])([CH3:3])[CH3:2].Br[CH2:18][CH2:19][CH2:20][O:21][CH3:22]>>[C:1]([C:5]1[CH:6]=[C:7]([C:14](=[O:16])[CH3:15])[CH:8]=[C:9]([O:13][CH2:18][CH2:19][CH2:20][O:21][CH3:22])[C:10]=1[O:11][CH3:12])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 5245511-Bromo-3-methoxypropaneHCID 581369461-(3-Tert-butyl-5-hydroxy-4-methoxyphenyl)ethanone

Product 1

HCID 580460241-[3-Tert-butyl-4-methoxy-5-(3-methoxypropoxy)phenyl]ethanoneYield 56.6%

Procedure

1-(3-tert-Butyl-5-hydroxy-4-methoxyphenyl)ethanone (O3.070; 2.00 g) and 1-bromo-3-methoxypropane (1.65 g) were converted, worked up and purified analogously to O2.110. 1.50 g of the title compound were obtained.

Workup

  1. custompurified analogously to O2

Sources & evidence

ORD record
ord-d9b8a773eb324317987328a8bdc5233a
Source dataset
uspto-grants-2015_07
Patent number
US09079906B2

Reaction notes

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