1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarbonyl chloride → HCID 178429401, compound

Participants

Reaction Conditions

Reaction Steps

To 1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarbonyl chloride (45 mg, 0.2 mmol) in pyridine (2 mL) was added 2-amino-6-methylpyrimidin-4-ol (25 mg, 0.2 mmol) and the reaction mixture was stirred at 115° C. for 15 hours. The solvent was evaporated to dryness and the residue redissolved in DMF, filtered and purified by reverse-phase preparative liquid chromatography utilizing a gradient of 0-99% acetonitrile in water containing 0.05% trifluoracetic acid to yield the pure product. ESI-MS m/z calc. 313.1. Found 314.1 (M+1)+. Retention time 2.31 minutes.

Provenance & Evidence