反应详情

N-Phthaloyl-L-phenylalanine (290 mg, 1 mmol) and 2-aminoacetophenone (171 mg, 1 mmol) were dissolved in 10 mL of pyridine. Bop reagent (470 mg, 1.1 mmol) was added The mixture was stirred at rt under N2 for 12 h. The solvent was removed. The residue was dissolved in EtOAc and washed with water and sat. NaHCO3. The organic layer was dried over Na2SO4, filtered, and concentrated to yield 412 mg of the product (100% yield). MS 413.2 (M+H)+.

1. customThe solvent was removed
2. dissolutionThe residue was dissolved in EtOAc
3. washwashed with water and sat. NaHCO3
4. dry with materialThe organic layer was dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated