4-Cyano-3-fluorobenzoic acid → n-((s)-1-(4-(3-Amino-1h-indazol-6-yl)-5-chloro-1h-imidazol-2-yl)-2-phenylethyl)-4-cyano-3-fluorobenzamide

HRID 1524870Notes

Reaction equation

HRID 1524870 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]3[N:12]=[C:13]([C@@H:17]([NH:25][C:26](=[O:32])OC(C)(C)C)[CH2:18][C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[NH:14][C:15]=3[Cl:16])=[CH:8][CH:9]=2)[NH:4][N:3]=1.[C:33]([C:35]1[CH:43]=[CH:42][C:38](C(O)=O)=[CH:37][C:36]=1[F:44])#[N:34]>>[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]3[N:12]=[C:13]([C@@H:17]([NH:25][C:26](=[O:32])[C:38]4[CH:42]=[CH:43][C:35]([C:33]#[N:34])=[C:36]([F:44])[CH:37]=4)[CH2:18][C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[NH:14][C:15]=3[Cl:16])=[CH:8][CH:9]=2)[NH:4][N:3]=1

Participants

3

Reactant 2

HCID 27784684-Cyano-3-fluorobenzoic acidHCID 131733133Tert-butyl (s)-1-(4-(3-amino-1h-indazol-6-yl)-5-chloro-1h-imidazol-2-yl)-2-phenylethylcarbamate

Product 1

HCID 66674749n-((s)-1-(4-(3-Amino-1h-indazol-6-yl)-5-chloro-1h-imidazol-2-yl)-2-phenylethyl)-4-cyano-3-fluorobenzamide

Procedure

The product from Example 122 Part B was coupled with 4-cyano-3-fluorobenzoic acid using the methods described in Part F of Example 120. MS: 500.3 (M+H)+.

Sources & evidence

ORD record
ord-e24df3fb4afb4b56a364219283d7c138
Source dataset
uspto-grants-2015_07
Patent number
US09079860B2

Reaction notes

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