Phenylacetic Acid → HCID 178453619, compound

Participants

Reaction Steps

The product from Example 159 Part B (132 mg, 0.23 mmol) and phenyl acetic acid (40 mg, 0.28 mmol) were dissolved in pyridine (0.7 mL, 0.71 mmol) and 1.5 mL of DMF. HOBt (45 mg, 0.3 mmol) and EDCI (60 mg, 0.30 mmol) were added to the flask, and the reaction was stirred at rt for 12 h. The reaction was diluted with EtOAc, extracted with ½ sat. brine (4-6 times), dried over MgSO4, filtered and evaporated to dryness to yield the desired product 150 mg (95% yield). MS 677 (M−H)−.

Provenance & Evidence