HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-methylnicotinic acid → 8-[1,2,3]Triazol-2-yl-naphthalene-1-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-methylnicotinic acid | HCID 121724 | — |
| Reactant | 8-Bromonaphthalene-2-carboxylic acid | HCID 14696378 | — |
| Reactant | 6-Methyl-2-[1,2,3]triazol-2-yl-nicotinic acid | HCID 67086855 | — |
| Product | 8-[1,2,3]Triazol-2-yl-naphthalene-1-carboxylic acid | HCID 67116459 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Intermediate 70 substituting 8-bromo-2-napthoic acid for 2-chloro-6-methylnicotinic acid. The desired 8-[1,2,3]triazol-2-yl-naphthalene-1-carboxylic acid was obtained (474 mg, 16%). MS (ESI): mass calculated for C1H9N3O2, 239.20; m/z found 240.3 [M+H]+. 1H NMR (400 MHz, CD3OD): 8.13 (t, J=9.0 Hz, 2H), 7.95-7.91 (m, 3H), 7.82 (dd, J=7.4, 1.0 Hz, 1H), 7.70 (dd, J=9.8, 5.8 Hz, 1H), 7.64-7.59 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079911B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-45d55b7adadf46b6b5e7a288c76bbee1 |
| Source note | uspto-grants-2015_07 |