2-(3-fluorophenyl)benzoic Acid → 2-[(3'-Fluorobiphenyl-2-yl)carbonyl]-5-(4-methylpyrimidin-2-yl)octahydro-pyrrolo[3,4-c]pyrrole

HRID 1524993Notes

Reaction equation

HRID 1524993 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:15][CH:14]3[CH:10]([CH2:11][NH:12][CH2:13]3)[CH2:9]2)[N:3]=1.[F:16][C:17]1[CH:18]=[C:19]([C:23]2[C:24]([C:29](O)=[O:30])=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:20]=[CH:21][CH:22]=1>>[F:16][C:17]1[CH:18]=[C:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[C:29]([N:12]2[CH2:13][CH:14]3[CH:10]([CH2:9][N:8]([C:4]4[N:3]=[C:2]([CH3:1])[CH:7]=[CH:6][N:5]=4)[CH2:15]3)[CH2:11]2)=[O:30])[CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 27826842-(3-fluorophenyl)benzoic AcidHCID 644589662-(4-Methyl-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole

Product 1

HCID 529171642-[(3'-Fluorobiphenyl-2-yl)carbonyl]-5-(4-methylpyrimidin-2-yl)octahydro-pyrrolo[3,4-c]pyrrole

Procedure

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 27 and 3′-fluoro-biphenyl-2-carboxylic acid. MS (ESI) mass calcd. for C24H23FN4O, 402.46; m/z found, 403.1 [M+H]+.

Sources & evidence

ORD record
ord-cad4642123cb445d899afde30ebc556b
Source dataset
uspto-grants-2015_07
Patent number
US09079911B2

Reaction notes

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