HRID1525011

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID44517264

5-Methyl-2-(pyrimidin-2-yl)benzoic acid

C12H10N2O2

结构：CN(C)c1nc(N2CC3CNCC3C2)cc(C(F)(F)F)n1

HCID67116323

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(-c2ncccn2)c(C(=O)N2CC3CN(c4cc(C(F)(F)F)nc(N(C)C)n4)CC3C2)c1

HCID67116603

[5-[2-(Dimethylamino)-6-(trifluoromethyl)-4-pyrimidinyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][5-methyl-2-(2-pyrimidinyl)phenyl]methanone

C25H26F3N7O

PROCEDURE

实验过程

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 36 and 5-methyl-2-pyrimidin-2-yl-benzoic acid. MS (ESI): mass calculated for C25H26F3N7O, 497.53; m/z found 498.0 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.67 (dd, J=20.0, 4.9, 2H), 8.20 (d, J=10.1, 1H), 7.34-7.30 (m, 1H), 7.19-7.15 (m, 1H), 7.13-7.03 (m, 1H), 5.85 (br s, 1H), 3.98-2.83 (m, 16H), 2.42 (s, 3H).