Crimidine → 2-[5-{[5-Fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-N,N,6-trimethylpyrimidin-4-amine

HRID 1525019노트

반응식

HRID 1525019 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:18]2[N:22]=[CH:21][CH:20]=[N:19]2)=[C:6]([C:8]([N:10]2[CH2:17][CH:16]3[CH:12]([CH2:13][NH:14][CH2:15]3)[CH2:11]2)=[O:9])[CH:7]=1.Cl[C:24]1[N:29]=[C:28]([N:30]([CH3:32])[CH3:31])[CH:27]=[C:26]([CH3:33])[N:25]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:18]2[N:22]=[CH:21][CH:20]=[N:19]2)=[C:6]([C:8]([N:10]2[CH2:11][CH:12]3[CH2:13][N:14]([C:24]4[N:29]=[C:28]([N:30]([CH3:32])[CH3:31])[CH:27]=[C:26]([CH3:33])[N:25]=4)[CH2:15][CH:16]3[CH2:17]2)=[O:9])[CH:7]=1

참가 물질

3

반응물 2

HCID 10813CrimidineHCID 67116387(5-Fluoro-2-[1,2,3]triazol-2-yl-phenyl)-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone

생성물 1

HCID 529178172-[5-{[5-Fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-N,N,6-trimethylpyrimidin-4-amine

실험 절차

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 21 and (2-chloro-6-methyl-pyrimidin-4-yl)-dimethyl-amine. MS (ESI): mass calculated for C22H25FN8O, 435.49; m/z found 437.3 [M+H]+. 1H NMR (400 MHz, CDCl3): 7.99-7.93 (m, 1H), 7.73 (s, 2H), 7.23-7.18 (m, 1H), 7.15-7.12 (m, 1H), 5.69 (s, 1H), 3.88-3.80 (m, 2H), 3.71-3.62 (m, 2H), 3.59-3.52 (m, 1H), 3.49-3.32 (m, 2H), 3.15-2.83 (m, 9H), 2.24 (s, 3H).

출처 및 근거

ORD 기록
ord-ecee4ff8ed6f4601a45a6ba89c4bcea6
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09079911B2

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