3-Fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid → HCID 67116820、化合物

関与物質

役割	名称	HCID	仕込み量
反応物	3-Fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid	HCID 67086549	—
反応物	6-Fluoro-2-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)quinazoline	HCID 69939155	—
生成物	HCID 67116820	HCID 67116820	—

反応手順

The title compound was prepared in a manner analogous to Example 15, utilizing Intermediate 43 and 3-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid. MS (ESI): mass calculated for C23H19F2N7O, 447.16; m/z found 448.1 [M+H]+. 1H NMR (500 MHz, CDCl3): 8.99 (s, 1H), 7.77 (d, J=15.8, 2H), 7.61 (dd, J=11.0, 5.5, 1H), 7.53-7.43 (m, 2H), 7.37-7.29 (m, 2H), 7.24 (s, 1H), 3.93 (d, J=9.9, 1H), 3.79 (dd, J=12.3, 7.4, 2H), 3.71-3.62 (m, 1H), 3.62 (s, 3H), 3.20 (dd, J=11.0, 5.3, 1H), 3.12-2.98 (m, 2H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09079911B2
出典データセット	uspto-grants-2015_07
ORD ID	ord-4b267cab2c044cd2844d89e08021d045
出典メモ	uspto-grants-2015_07