5-Methoxy-2-(2H-1,2,3-triazol-2-yl)benzoic acid → (5-(6,7-Difluoroquinoxalin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

HRID 1525078ノート

反応式

HRID 1525078 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[N:8]=[C:7]([N:13]1[CH2:20][CH:19]3[CH:15]([CH2:16][NH:17][CH2:18]3)[CH2:14]1)[CH:6]=[N:5]2.[CH3:21][O:22][C:23]1[CH:24]=[CH:25][C:26]([N:32]2[N:36]=[CH:35][CH:34]=[N:33]2)=[C:27]([CH:31]=1)[C:28](O)=[O:29]>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[N:8]=[C:7]([N:13]1[CH2:14][CH:15]3[CH2:16][N:17]([C:28]([C:27]4[CH:31]=[C:23]([O:22][CH3:21])[CH:24]=[CH:25][C:26]=4[N:32]4[N:36]=[CH:35][CH:34]=[N:33]4)=[O:29])[CH2:18][CH:19]3[CH2:20]1)[CH:6]=[N:5]2

参加物

3

反応物 2

HCID 670865655-Methoxy-2-(2H-1,2,3-triazol-2-yl)benzoic acidHCID 699386886,7-Difluoro-2-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)quinoxaline

生成物 1

HCID 67116647(5-(6,7-Difluoroquinoxalin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

実験手順

The title compound was prepared in a manner analogous to Example 15, utilizing Intermediate 44 and 5-methoxy-2-(2H-1,2,3-triazol-2-yl)benzoic acid. MS (ESI): mass calculated for C24H21F2N7O2, 477.2; m/z found 478.1 [M+H]+. 1H NMR (500 MHz, CDCl3): 8.25 (s, 1H), 7.84 (t, J=7.6, 1H), 7.64 (dt, J=19.7, 10.8, 3H), 7.42 (dd, J=11.4, 8.0, 1H), 7.03 (dd, J=9.0, 2.8, 1H), 6.92 (d, J=2.8, 1H), 3.97-3.84 (m, 5H), 3.64 (dd, J=18.2, 14.6, 5H), 3.12 (dd, J=19.8, 8.6, 3H).

出典と根拠

ORDレコード
ord-cab6f91a275640358e7adda886662841
出典データセット
uspto-grants-2015_07
特許番号
US09079911B2

反応ノート

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