2-Bromopyridine-3-carboxylic acid → (2-Bromopyridin-3-yl)(5-(4,5,6-trimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone

HRID 1525081Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1525081
[CH3:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[N:5]=[C:4]([N:10]2[CH2:17][CH:16]3[CH:12]([CH2:13][NH:14][CH2:15]3)[CH2:11]2)[N:3]=1.[Br:18][C:19]1[C:24]([C:25](O)=[O:26])=[CH:23][CH:22]=[CH:21][N:20]=1>>[Br:18][C:19]1[C:24]([C:25]([N:14]2[CH2:13][CH:12]3[CH:16]([CH2:17][N:10]([C:4]4[N:5]=[C:6]([CH3:9])[C:7]([CH3:8])=[C:2]([CH3:1])[N:3]=4)[CH2:11]3)[CH2:15]2)=[O:26])=[CH:23][CH:22]=[CH:21][N:20]=1

Komponenten

3

Edukt 2

HCID 2332622-Bromopyridine-3-carboxylic acidHCID 699393982-(4,5,6-Trimethylpyrimidin-2-yl)octahydropyrrolo[3,4-c]pyrrole

Produkt 1

HCID 86669171(2-Bromopyridin-3-yl)(5-(4,5,6-trimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone

Versuchsvorschrift

The title compound was prepared in a manner analogous to Example 1 utilizing Intermediate 42 and 2-bromopyridine-3-carboxylic acid. MS (ESI): mass calculated for C19H22BrN5O, 415.10; m/z found 416.1 [M+H]+. 1H NMR (600 MHz, CDCl3): 8.44 (dd, J=4.7, 1.6, 1H), 7.33 (dd, J=7.6, 4.7, 1H), 6.38-6.24 (m, 1H), 3.94-3.90 (m, 2H), 3.88-3.84 (m, 1H), 3.74-3.50 (m, 4H), 3.31-3.01 (m, 3H), 2.40-2.23 (m, 6H), 2.12-2.06 (m, 3H).

Quellen und Nachweise

ORD-Eintrag
ord-6e64bfe2e6e24c079f6a05b065da2b4b
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09079911B2

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