2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid → (5-(4,6-Dimethoxypyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Participants

Role	Name	HCID	Charge
Reactant	2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid	HCID 67086627	—
Reactant	2-(4,6-Dimethoxy-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole	HCID 67116491	—
Product	(5-(4,6-Dimethoxypyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone	HCID 69939595	—

Reaction Steps

The title compound was prepared in a manner analogous to Example 15, utilizing Intermediate 45 and Intermediate 12. MS (ESI): mass calculated for C21H22FN7O3, 439.18; m/z found 440.2 [M+H]+. 1H NMR (400 MHz, CDCl3): 7.89-7.80 (m, 2H), 7.73 (s, 1H), 7.53-7.43 (m, 1H), 7.15 (tdd, J=8.4, 3.7, 0.9, 1H), 5.39 (d, J=2.4, 1H), 4.02-3.48 (m, 13H), 3.31-2.89 (m, 3H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09079911B2
Source dataset	uspto-grants-2015_07
ORD ID	ord-3b7d8a38478b4528801ec2989e43082b
Source note	uspto-grants-2015_07