Ethanolamine → HCID 178472034, 화합물

HRID 1525127노트

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HRID 1525127 반응식
[CH2:1]([O:3][C:4](=[O:21])[C:5](=[CH:17]OCC)[C:6](=[O:16])[C:7]1[C:8]([Cl:15])=[N:9][C:10]([Cl:14])=[C:11]([F:13])[CH:12]=1)[CH3:2].[CH2:22]([CH2:24][NH2:25])[OH:23]>CCOCC>[Cl:15][C:8]1[N:9]=[C:10]([Cl:14])[C:11]([F:13])=[CH:12][C:7]=1[C:6](/[C:5](=[CH:17]/[NH:25][CH2:24][CH2:22][OH:23])/[C:4]([O:3][CH2:1][CH3:2])=[O:21])=[O:16]

참가 물질

4

반응물 2

HCID 700EthanolamineHCID 54342804Ethyl 2-(2,6-dichloro-5-fluoronicotinoyl)-3-ethoxyacrylate

생성물 1

HCID 178472034HCID 178472034, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 2,6-dichloro-α-(ethoxymethylene)-5-fluoro-β-oxo-3-pyridinepropanoic acid ethyl ester (1.00 g; prepared according to EP 132845) was treated with ethanolamine (0.18 mL). After a few minutes, the reaction mixture became sticky and was diluted with Hept/ether (1:1; 10 mL). After further stirring at rt for 1.5 h, the solvents were evaporated under reduced pressure and the crude yellow oil was directly used in the next step.

후처리

  1. waitAfter a few minutes
  2. customthe solvents were evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-6bca1d89d3284b12a828f59fd03bd676
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09079922B2

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