Sodium Hydroxide → HCID 131733135, compound

HRID 1525132Notes

Reaction equation

HRID 1525132 reaction equation
[C:1]([CH:8]([CH2:12][CH2:13][CH2:14][CH2:15][NH2:16])[C:9]([OH:11])=[O:10])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[OH-].[Na+].[N+]([O-])([O-])=O.[Ag+:23]>O>[Ag+:23].[C:1]([CH:8]([CH2:12][CH2:13][CH2:14][CH2:15][NH2:16])[C:9]([O-:11])=[O:10])([O:3][C:4]([CH3:6])([CH3:7])[CH3:5])=[O:2]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24470Silver NitrateHCID 18470676HCID 18470676, compound

Product 1

HCID 131733135HCID 131733135, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Boc-6-aminohexanoic acid (0.85 g, 3.68 mmol) was added to water (4 mL) and cooled in ice bath. To this suspension 1N NaOH was added with constant stirring until the pH of solution was about 7 and the mixture became a clear solution. To this solution, silver nitrate (0.63 g, 3.68 mmol) in water (2 mL) was added slowly. The resulting precipitate was filtered and washed with water. The solid was dried in vacuum over phosphorus pentoxide to yield a white solid (1.09 g) (yield, 88%).

Workup

  1. temperaturecooled in ice bath
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with water
  4. dry with materialThe solid was dried in vacuum over phosphorus pentoxide

Sources & evidence

ORD record
ord-4a1f596e46fd47e2a383748267a7650c
Source dataset
uspto-grants-2015_07
Patent number
US09079928B2

Reaction notes

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