Acetophenone → 1-Phenylethanol, (S)-

Participants

Reaction Conditions

Reaction Steps

Under nitrogen stream, acetophenone (20 mmol), RuCl[(S)-xylbinap][(S)-daipen] (1/100 molar fold of acetophenone) and t-BuOK (5 molar folds of the ruthenium catalyst) were added to a Schlenk tube. 2-propanol (8.3 mL per 100 mg of acetophenone) was added, then stirred for 10 minutes at 30° C. As a result of analysis of the reaction mixture by gas chromatography (Chirasil-DEX CB), it was found that the conversion rate is 94%, and the optical purity is 98.4% ee.

Provenance & Evidence