Ethyl bromodifluoroacetate → 1-Naphthaleneacetic acid, 7-bromo-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]-α,α,4,4-tetrafluoro-1,2,3,4-tetrahydro-, ethyl ester, (1R)-

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Reaction Steps

Starting from (R)-2-methyl-propane-2-sulfinic acid [7-bromo-4,4-difluoro-3,4-dihydro-2H-naphthalen-(1E)-ylidene]-amide (intermediate A2.4) and ethyl 2-bromo-2,2-difluoroacetate, the product [(R)-7-bromo-4,4-difluoro-1-((R)-2-methyl-propane-2-sulfinylamino)-1,2,3,4-tetrahydro-naphthalen-1-yl]-difluoro-acetic acid ethyl ester (58% yield) was obtained as a brown solid. MS (ISP): m/z=488.1 [M+H]+ and 490.0 [M+H]+.

Provenance & Evidence