5-Chloropyridine-3-boronic acid → HCID 71059559, compound

Participants

Reaction Steps

In a manner analogous to that described in Example 19, the cross coupling reaction of (2′R,4R)-6′-bromo-5,5-difluoro-5,5″,6,6″-tetrahydro-4″H-dispiro[1,3-oxazine-4,4′-chromene-2′,3″-pyran]-2-amine (intermediate B6.7) with 5-chloropyridin-3-ylboronic acid and chromatography on preparative HPLC yielded the title compound (66% yield) as an off-white, amorphous material. MS (ISP): m/z=436 [M+H]+ and 438 [M+2+H]+.

Provenance & Evidence