5-(trifluoromethyl)pyridine-2-carboxylic Acid → HCID 71059463, compound

HRID 1525192Notes

Reaction equation

HRID 1525192 reaction equation
[F:1][C:2]1([F:26])[CH2:8][O:7][CH2:6][C:5]([NH2:9])=[N:4][C@@:3]21[C:18]1[C:13](=[CH:14][CH:15]=[C:16]([NH2:19])[CH:17]=1)[O:12][CH:11]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:10]2.[F:27][C:28]([F:39])([F:38])[C:29]1[CH:30]=[CH:31][C:32]([C:35](O)=[O:36])=[N:33][CH:34]=1>>[NH2:9][C:5]1[CH2:6][O:7][CH2:8][C:2]([F:1])([F:26])[C@@:3]2([C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH:19][C:35](=[O:36])[C:32]4[CH:31]=[CH:30][C:29]([C:28]([F:38])([F:27])[F:39])=[CH:34][N:33]=4)[CH:17]=3)[O:12][CH:11]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:10]2)[N:4]=1

Participants

3

Reactant 2

HCID 109103495-(trifluoromethyl)pyridine-2-carboxylic AcidHCID 86674118HCID 86674118, compound

Product 1

HCID 71059463HCID 71059463, compoundYield 7%

Procedure

The condensation of (2RS,4R)-6′,6′-difluoro-2-phenyl-6′,7′-dihydro-2′H-spiro[chroman-4,5′-[1,4]oxazepine]-3′,6-diamine (intermediate C4.3) and 5-trifluoromethyl-pyridine-2-carboxylic acid yielded the title compound (7% yield) as a light brown solid. MS (ISP): m/z=532.8 [M+H]+.

Sources & evidence

ORD record
ord-dcebbe78e9c644a69764108159c4e10f
Source dataset
uspto-grants-2015_07
Patent number
US09079919B2

Reaction notes

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