反应详情

The cross coupling reaction of (2RS,4R)-6-bromo-6′,6′-difluoro-2-phenyl-6′,7′-dihydro-2′H-spiro[chroman-4,5′-[1,4]oxazepin]-3′-amine (intermediate C3.4) with 3,5-dichlorophenylboronic acid yielded the title compound (8% yield) as a white solid. MS (ISP): m/z=489.4 [M+H]+.