Diethyl amino(4-methoxyphenyl)methylphosphonate → HCID 178476980, compound

HRID 1525234Notes

Reaction equation

HRID 1525234 reaction equation
[NH2:1][CH:2]([P:11](=[O:18])([O:15][CH2:16][CH3:17])[O:12][CH2:13][CH3:14])[C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][CH:4]=1.[OH:19][C:20]1[C:25]([C:26](O)=[O:27])=[CH:24][N:23]=[C:22]([N:29]2[CH:33]=[CH:32][CH:31]=[N:30]2)[N:21]=1.OC1C(C(NC(C2C=CC=CC=2)C2C=CC(P(=O)(OCC)OCC)=CC=2)=O)=CN=C(N2C=CC=N2)N=1>>[OH:19][C:20]1[C:25]([C:26]([NH:1][CH:2]([P:11](=[O:18])([O:12][CH2:13][CH3:14])[O:15][CH2:16][CH3:17])[C:3]2[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][CH:4]=2)=[O:27])=[CH:24][N:23]=[C:22]([N:29]2[CH:33]=[CH:32][CH:31]=[N:30]2)[N:21]=1

Participants

4

Reactant 3

HCID 419298Diethyl amino(4-methoxyphenyl)methylphosphonateHCID 178476968HCID 178476968, compoundHCID 178524762HCID 178524762, compound

Product 1

HCID 178476980HCID 178476980, compound

Procedure

Compound 10-1 was prepared from compound 10-b and compound 8-b in a similar manner as the synthesis of compound 8-1. 1H NMR (300 MHz, DMSO-d6) δ1.09-1.20 (m, 6H), 3.73 (s, 3H), 3.84-4.04 (m, 4H), 5.44-5.54 (m, 1H), 6.71-6.73 (m, 1H), 6.92-6.94 (m, 2H), 7.30-7.33 (m, 2H), 8.06 (s, 1H), 8.41 (brs, 1H), 8.60-8.61 (m, 1H). LC-MS: (M+H)+ 462.

Sources & evidence

ORD record
ord-bed900ba5d2444b0a005774c938ee788
Source dataset
uspto-grants-2015_07
Patent number
US09079930B2

Reaction notes

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