反应详情

Ethyl 4-((R)—((R)-1,1-dimethylethylsulfinamido)(4-fluorophenyl)methyl)phenyl(methyl)phosphinate, 18-d, (7 g, 18 mmol) was dissolved in HCl/dioxane (50 ml) and the mixture was stirred at room temperature for about 3 h. The mixture was then concentrated under vacuum and the residue was washed with ethyl acetate to provide the product, 18-e, (4.4 g, 80%).

1. concentrationThe mixture was then concentrated under vacuum
2. washthe residue was washed with ethyl acetate