1,4-Dioxane hydrochloride → Ethyl 4-((S)-amino(4-fluorophenyl)methyl)phenyl(methyl)phosphinate hydrochloride

Participants

Reaction Steps

Ethyl 4-((S)—((S)-1,1-dimethylethylsulfinamido)(4-fluorophenyl)-methyl)phenyl(methyl)phosphinate, 19-c, (10.6 g, 27 mmol) was dissolved in HCl/dioxane (100 ml) and the mixture was stirred at room temperature for about 3 h. The mixture was then concentrated under vacuum and the residue was washed with ethyl acetate to provide the product, 19-d, (6.66 g, 80%).

Provenance & Evidence