1,4-Dioxane hydrochloride → Methyl 4-((R)-amino(2,4-difluorophenyl)methyl)phenyl(methyl)phosphinate hydrochloride

Participants

Reaction Steps

Ethyl 4-((R)-(2,4-difluorophenyl)((R)-1,1-dimethylethylsulfinamido)methyl)-phenyl(methyl)phosphinate, 20-d, (866 mg, 2.5 mmol) was dissolved in HCl/dioxane (5 ml) and the mixture was stirred at room temperature for 1 h. Then it was concentrated under vacuum and the residue was washed with ethyl acetate to provide the product 20-e (781 mg, 96%).

Provenance & Evidence