1,4-Dioxane hydrochloride → Ethyl 4-((S)-amino(2,4-difluorophenyl)methyl)phenyl(methyl)phosphinate hydrochloride

Participants

Reaction Steps

Ethyl 4-((S)-(2,4-difluorophenyl)((S)-1,1-dimethylethylsulfinamido)methyl)phenyl(methyl)phosphinate, 21-c, (950 mg, 2.2 mmol) was dissolved in HCl/dioxane (5 ml) and the mixture was stirred at room temperature for 1 h. Then it was concentrated under vacuum and the residue was washed with ethyl acetate to provide the product, 21-d, (700 mg, 88%).

Provenance & Evidence