HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1525286Generated: November 4, 2026
3-Bromobenzaldehyde → HCID 89462449, compound
https://huagongshe.com/reaction/1525286
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromobenzaldehyde | HCID 76583 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | tert-Butylsulfinamide, (S)-(-)- | HCID 11355477 | — |
| Catalyst | Copper Sulfate | HCID 24462 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 89462449 | HCID 89462449 | 52% |
Reaction Steps
3-bromobenzaldehyde, 24-a, (30 g, 162 mmol) in dichloromethane (600 ml) were added (S)-2-methylpropane-2-sulfinamide (23.52 g, 194.5 mmol), PPTS (5.97 g, 16.2 mmol) and anhydrous CuSO4 (78 g, 486 mmol) and the resulting mixture was stirred at 37° C. overnight. The mixture was then filtrated and the filtrate was concentrated under vacuum. The residue was purified by column chromatography (petroleum ether/ethyl acetate=5/1) to provide the product, 25-a, (24.5 g, 52%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09079930B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-9b4311da15b54bca82d590c9d5616fee |
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| Source note | uspto-grants-2015_07 |
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